Human papillomavirus (HPV) deregulation of Toll-like receptor 9

نویسنده

  • Uzma Hasan
چکیده

Persistent infection by high-risk human papillomavirus (HPV) is associated with cervical carcinoma. Blocking innate immune responses in the cervix is critical for the establishment of persistent infections. Here, we discuss how HPV-16-encoded factors suppress the activity of Toll-like receptor 9, which plays a major role in innate antiviral immune responses.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Toll-Like Receptor Transcriptome in the HPV-Positive Cervical Cancer Microenvironment

The human papillomavirus (HPV) directly infects cervical keratinocytes and interferes with TLR signalling. To shed light on the effect of HPV on upstream receptors, we evaluated TLRs 1-9 gene expression in HPV-negative normal and HPV-positive pre-malignant and malignant ex vivo cervical tissue. Quantitative real-time polymerase chain reaction was performed separately for epithelial and stromal ...

متن کامل

Involvement of the Toll-Like Receptor/Nitric Oxide Signaling Pathway in the Pathogenesis of Cervical Cancer Caused by High-Risk Human Papillomavirus Infection

Human papillomavirus (HPV) can activate Toll-like receptor (TLR)/nitric oxide (NO) signaling pathways; however, whether the TLR/NO pathway is involved in cervical cancer caused by high-risk HPV (HR-HPV) remains unclear. In this study, 43 HR-HPV-positive patients with cervical cancer (CC group), 39 HR-HPV-positive patients with a healthy cervix (HR-HPV group), and 33 HR-HPV-negative controls wer...

متن کامل

Effects of high mobility group protein box 1 and toll like receptor 4 pathway on warts caused by human papillomavirus

Accumulative evidence has demonstrated that inflammation has an important role in human papillomavirus (HPV) oncogenicity. However, the effects of high mobility group protein box 1 (HMGB1)-toll like receptor 4 (TLR4) signaling pathway associated inflammation on epidermal warts caused by HPV remain unclear. The present study investigated the HMGB1, TLR4 and nuclear factor-κB p65 expression in co...

متن کامل

Prevalence of Human Papillomavirus In Women With Abnormal Pap Smear In Boyer Ahmad City

  Abstract Background & aim: Human papillomavirus (HPV) is the most common sexually transmitted disease that is major risk factor for the development of precancerous and cancerous cervical lesions. This study was planned to evaluate the prevalence of HPV and its genotypes in women with abnormal Pap smear who referred to shahid Mofateh clininc. Methods: A total of 67 cervical cytology sample inc...

متن کامل

Role of the Human Papillomavirus Infectio in Esophageal Squamous Cell Carcinoma

Background and Objective: Human papillomavirus (HPV) is one of the possible etiologic factors  in development of esophageal squamous cell carcinoma (ESCC). In this study we aimed to study the  role of HPV in ESCC. Patients and Methods:In this study, 140 cases of ESCC were analyzed for the HPV DNA by  polymerase chain reaction (PCR) using GP5+/GP6+ primers for L1 open reading frame (ORF) to  am...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2014